SCD Cardiovascular, Pulmonary, and Renal

Release Date:

July 30, 2015

Scope of Collection

Element Considered	Final Measures in Toolkit
N-terminal-pro-brain natriuretic peptide (NT-proBNP)	N-terminal-pro-brain natriuretic peptide (NT-proBNP)
Cardiovascular Complications
Right Heart Catheterization (RHC)	Right Heart Catheterization (RHC)
Iron overload	Serum or Plasma Ferritin
Hemolytic Component	Reticulocyte Count
	Haptoglobin Level
	Bilirubin Level
	Lactate Dehydrogenase Level
	Red Blood Cell Aspartate Aminotransferase Level
Brachial Artery Relaxivity
Short Axis Function
Pulmonary Complications
Asthma/airways disease	Lung Function - Diffusion Capacity
	Lung Function - Lung Volume
Acute chest syndrome	Chest X-ray
Sleep Disordered Breathing
Other Complications
Temperature	Body Temperature
Liver iron

Working Group Roster:

WG Members:

Elizabeth S. Klings, MD, Chair Boston University School of Medicine Boston, MA	Carol Blaisdell, MD National Heart, Lung, and Blood Institute (NHLBI) Bethesda, MD
Jon A. Detterich, MD Children's Hospital Los Angeles Los Angeles, CA	Antonio Guasch, MD Emory University Atlanta, GA
Johnson Haynes, MD University of South Alabama Mobile, AL	Vandana Sachdev, MD National Heart, Lung, and Blood Institute (NHLBI) Bethesda, MD
John Wood, MD, PhD Children's Hospital Los Angeles Los Angeles, CA

Sickle Cell Disease Panel Liaison, WG Manager and WG Supervisor:

Tracey L. Grant, MS, WG Manager RTI International Statistics and Epidemiology Division Research Triangle Park, NC	Wayne Huggins, PhD, WG Supervisor RTI International Research Triangle Park, NC

Sickle Cell Disease Research and Scientific Panel (SRSP) Liaison:

James R. Eckman, MD Emory University School of Medicine Atlanta, GA	Kathryn L. Hassell, MD University of Colorado, Denver Denver, CO

Supplemental Information includes protocols that the Working Group or Expert Review Panel considered useful and highly relevant to the domain but do not meet the criteria for inclusion in the Toolkit.

Sickle Cell Disease: Cardiovascular, Pulmonary, and Renal Specialty Collection Supplemental Information includes:

• Sleep Disordered Breathing 16June2015
• Short Axis Function 20May2015
• Liver Iron-20May2015
• Cell Free Hemoglobin 09July2015
• Brachial Artery Relaxivity-20May2015
• 01 SCD WG1 Specialty Collection Scope

Additional Information:

There is no additional information for this collection.

Measure		Protocols	Domain/Collection
Abdominal Aortic Aneurysm	Add to My Toolkit	Abdominal Aortic Aneurysm	Cardiovascular
Arterial Blood Gas (ABG)	Add to My Toolkit	Arterial Blood Gas (ABG)	Respiratory
Aspartate Aminotransferase	Add to My Toolkit	Aspartate Aminotransferase Level	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
Bilirubin Level	Add to My Toolkit	Bilirubin Level	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
Blood Pressure (Adult/Primary)	Add to My Toolkit	Blood Pressure (Adult/Primary)	Cardiovascular
Body Temperature	Add to My Toolkit	Body Temperature - Oral Thermometers	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
	Add to My Toolkit	Body Temperature - Tympanic Thermometers	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
Chest Computed Tomography (CT)	Add to My Toolkit	Chest Computed Tomography (CT)	Respiratory
Chest X-ray	Add to My Toolkit	Chest X-ray	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
Deep Venous Thrombosis	Add to My Toolkit	Deep Venous Thrombosis	Cardiovascular
Exercise Capacity/Six-Minute Walk Test	Add to My Toolkit	Exercise Capacity/Six-Minute Walk Test	Respiratory
Haptoglobin Level	Add to My Toolkit	Haptoglobin Level	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
Heart Valve Function	Add to My Toolkit	Heart Valve Function	Cardiovascular
History of Stroke - Ischemic Infarction and Hemorrhage	Add to My Toolkit	History of Stroke - Ischemic Infarction and Hemorrhage	Neurology
Lactate Dehydrogenase Level	Add to My Toolkit	Lactate Dehydrogenase Level	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
Lung Function - Diffusion Capacity	Add to My Toolkit	Lung Function - Diffusion Capacity	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
Lung Function - Lung Volume	Add to My Toolkit	Lung Function - Lung Volume	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
N-terminal Pro-brain Natriuretic Peptide (NT-proBNP)	Add to My Toolkit	N-terminal Pro-brain Natriuretic Peptide (NT-proBNP)	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
Peak Expiratory Flow Rate (PEFR)	Add to My Toolkit	Peak Expiratory Flow Rate (PEFR)	Respiratory
Peripheral Arterial Disease	Add to My Toolkit	Peripheral Arterial Disease	Cardiovascular
Personal History of Kidney Failure	Add to My Toolkit	Personal History of Kidney Failure	Diabetes
Pulmonary Embolism	Add to My Toolkit	Pulmonary Embolism	Cardiovascular
Respiratory Rate	Add to My Toolkit	Respiratory Rate - Adult	Respiratory
	Add to My Toolkit	Respiratory Rate - Child	Respiratory
	Add to My Toolkit	Respiratory Rate - Infant	Respiratory
Reticulocyte Count	Add to My Toolkit	Reticulocyte Count	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
Serum Creatinine Assay	Add to My Toolkit	Serum Creatinine - Assay	Diabetes
Serum or Plasma Ferritin	Add to My Toolkit	Serum or Plasma Ferritin	SCD: Cardiovascular, Pulmonary, and Renal Specialty Collection
Sleep Apnea	Add to My Toolkit	Sleep Apnea - Adult	Respiratory
	Add to My Toolkit	Sleep Apnea - Child	Respiratory
Spirometry	Add to My Toolkit	Spirometry - Adult	Respiratory
	Add to My Toolkit	Spirometry - Child	Respiratory
Urinary Creatinine Assay	Add to My Toolkit	Urinary Creatinine - Assay	Diabetes
Urinary Microalbumin Assay	Add to My Toolkit	Urinary Microalbumin - Assay	Diabetes