Protocol - Lung Function - Lung Volume

Personnel and Training Required

Certified respiratory therapist

Equipment Needs

Equipment needed for the calculation of lung volumes are outlined in the American Thoracic Society (ATS) and the European Respiratory Society (ERS) Task Force recommendations for standardisation of the measurement of lung volumes can be found here as well as on the ATS website here.

Requirements

Requirement Category	Required
Major equipment	Yes
Specialized training	Yes
Specialized requirements for biospecimen collection	No
Average time of greater than 15 minutes in an unaffected individual	No

Mode of Administration

Clinical assessment

Lifestage

Child, Adolescent, Adult, Senior, Pregnancy

Participants

Individuals age 8 years old and older.

Selection Rationale

The Sickle Cell Disease Cardiovascular, Pulmonary, and Renal Working Group recommends the American Thoracic Society (ATS) and the European Respiratory Society (ERS) Task Force 2005 recommendations for standardisation of the measurement of lung volumes because this document integrates and consolidates the task force recommendations and the recommendations from various National Heart, Lung, and Blood Institute (NHLBI) workshops.

Language

English

Standards

Standard	Name	ID	Source
Human Phenotype Ontology	Restrictive ventilatory defect	HP:0002091	HPO
caDSR Form	PhenX PX810401 - Lung Function Lung Volume	6252184	caDSR Form

Derived Variables

None

Process and Review

Not applicable.

Protocol Name from Source

Wanger, J. et al. Standardization of the measurement of lung volumes. EUR RESPIR J, 2005

Source

Wanger, J., Clausen, J. L., Coates, A., Pedersen, O. F., Brusasco, V., Burgos, F., Casaburi, R., Crapo, R., Enright, P., van der Grinten, C. P. M., Gustafsson, P., Hankinson, J., Jensen, R., Johnson, D., MacIntyre, N., McKay, R., Miller, M. R., Navajas, D., Pellegrino, R., & Viegi, G. (2005). Standardisation of the measurement of lung volumes. European Respiratory Journal, 26, 511-522. doi: 10.1183/09031936.05.00035005

General References

Arteta, M., Campbell, A., Nouraie, M., Rana, S., Onyekwere, O. C., Ensing, G., Sable, C., Dham, N., Darbari, D., Luchtman-Jones, L., Kato, G. J., Gladwin, M. T., Castro, O. L., Minniti, C. P., & Gordeuk, V. R. (2014). Abnormal pulmonary function and associated risk factors in children and adolescents with sickle cell anemia. Journal of Pediatric Hematology/Oncology, 36(3), 185-189.

Lunt, A., Desai, S. R., Wells, A. U., Hansell, D. M., Mushemi, S., Melikian, N., Shah, A. M., Thein, S. L., & Greenough, A. (2014). Pulmonary function, CT and echocardiographic abnormalities in sickle cell disease, Thorax 69(8), 746-751.

Protocol ID

810401

Variables

Export Variables

Variable Name	Variable ID	Variable Description	dbGaP Mapping
PX810401_Standardisation_LungVolumeMeasurement_BodyPleth_Calibration
	PX810401390105	If body plethysmography method is used to more measure FRC, was the mouth pressure transducer and plethysmograph signal calibrated within the past 24 hours? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_BodyPleth_ConstantPressure_Airflow
	PX810401390101	If flow plethysmograph, what is the airflow more rate in and out of the constant-pressure chamber? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_BodyPleth_ConstantVolume
	PX810401390201	If variable-pressure plethysmograph, what is more the pressure within the constant-volume chamber? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_BodyPleth_Measurement_Technique
	PX810401390103	If body plethysmography method is used to more measure FRC, does the measurement technique adhere to the following steps? 1) Equipment should be turned on and allowed an adequate time to warm up; 2) Equipment is set up for testing, including calibration, show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Current_Temperature
	PX810401140000	What is the current ambient temperature?	Variable Mapping
PX810401_Standardisation_LungVolumeMeasurement_Current_Time
	PX810401160000	What is the current time?	N/A
PX810401_Standardisation_LungVolumeMeasurement_Equipment_OpenCircuit_Replacement
	PX810401240000	Since the previous subject, if an more open-circuit technique was used and the subject only expires into the spirometer, was the portion of the circuit which rebreathing occurs properly decontaminated? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Equipment_Reusable_Components
	PX810401220000	Has reusable equipment (such as mouthpieces, more breathing tubes, valves and manifolds or any other equipment showing visible condensation from expired air) been disinfected/sterilized? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_FirstMethod_Frc
	PX810401370201	If first method, what is the reported value more for the functional residual capacity (mean of technically satisfactory FRC measurements)? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_FirstMethod_Ivc
	PX810401370203	If first method, what is the reported value more for the (technically satisfactory) inspiratory vital capacity (IVC)? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Helium_Analyzer_Range
	PX810401410600	If helium dilution method is used to measure more FRC, does the helium analyzer have a range of ~0-10% helium, a resolution of <= 0.01% helium over the entire range, and a 95% response time of <15seconds to a 2% step change in helium concentration? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Helium_Analyzer_Type
	PX810401410400	If helium dilution method is used to measure more FRC, what type of analyzer is being used? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Helium_CalibrationStep
	PX810401410200	If helium dilution method is used to measure more FRC, before measurements are taken, was enough 100% helium added to the system where the helium reading was ~10%? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Helium_Calibration_Control
	PX810401411800	If helium dilution method is used to measure more FRC, was testing of biological controls performed at least once in the past month? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Helium_CarbonDioxide
	PX810401411000	If helium dilution method is used to measure more FRC, is the breathing-circuit CO2 levels during testing below 0.5%? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Helium_Leak_Check
	PX810401411600	If helium dilution method is used to measure more FRC, for systems that can be pressurized, were leaks checked for at least once in the past 24 hours and/or after every tubing or canister changes? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Helium_Measurement_Technique
	PX810401411400	If helium dilution method is used to measure more FRC, does the measurement technique adhere to the following steps? 1) Equipment is turned on and allowed an adequate warm-up time, with calibration as instructed by manufacturer; 2) The equipment should be show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Helium_Oxygen_Recalibration
	PX810401410800	If helium dilution method is used to measure more FRC, for systems in which O2 concentration changes substantially, was the helium analyzer recalibrated over the range of O2 concentrations encountered? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Helium_Temperature_Sensor
	PX810401411200	If helium dilution method is used to measure more FRC, does the temperature sensor have an accuracy of better than 0.5 degrees Celsius over the range of 12-30 degrees Celsius and have a 90% response time of <30 seconds to a 5 degree Celsius step change of show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Imaging_Technique_Other
	PX810401420300	If the subject has limited ability to more cooperate, which imaging technique method will be used to measure his/her lung volume? Other show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Inline_Filtered
	PX810401280000	If in-line filters are being used, does the more measuring system meet the minimum recommendations for accuracy, precision (reproducibility), flow resistance, and back pressure with the filter installed? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Method_Frc
	PX810401380000	Which method is used for measuring forced more residual capacity (FRC)? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Nitrogen_Calibration_Controls
	PX810401400900	If nitrogen washout method is used to more measure FRC, was the performance of the device tested with biological controls at least once in the past month? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Nitrogen_Measurement_Technique
	PX810401400500	If nitrogen washout method is used to more measure FRC, does the measurement technique adhere to the following steps? 1) Equipment is turned on and allowed an adequate warm-up time, with calibration as instructed by manufacturer; 2) Patient should be aske show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Nitrogen_Quality_Control
	PX810401400100	If nitrogen washout method is used to more measure FRC, does the N2 analyzer have an inaccuracy <= 0.2% of full range throughout the entire measuring range (0-80%), have a resolution of <= 0.01%, and have a 95% analyzer response time of <= 60 milliseconds show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Nitrogen_Recalibration
	PX810401400700	If nitrogen washout method is used to more measure FRC, before initial use and once every 6 months thereafter, was the linearity of the N2 analyzer confirmed by measuring the N2 percentage of a calibration gas mixture, where the expected N2 concentration show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Nitrogen_SamplingRate
	PX810401400300	If nitrogen washout method is used to more measure FRC, for flow and nitrogen signals, does the system have a sampling rate of >= 40 samples/sec? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Personnel_FormalTraining
	PX810401300000	For personnel directly involved in pulmonary more function testing, do they have formal training emphasis in health-related sciences (such as nursing, medical assistant, respiratory therapy, etc)? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Personnel_Notebook_Detail
	PX810401360000	Are there detailed statements and/or more publications on the selection of references values and interpretation of lung function tests along with an assessment of the reliability of the data? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Personnel_RefreshTraining
	PX810401340000	If it has been more than 3 years since more his/her last competency exam or if lung function standards have been recently updated, have personnel taken a spirometry refresher training course? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Personnel_TrainingProgram
	PX810401320000	Has personnel completed training similar to more the National Institute for Occupational Safety and Health (NIOSH)-approved spirometry program? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_SecondMethod_Approach_Ic
	PX810401370306	If second method, and using the slow EVC more approach, what is the mean of technically satisfactory inspiratory capacity (IC) measurements? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_SecondMethod_Approach_Ivc
	PX810401370304	If second method, and using the IVC/ERV more approach, what is the reported value for the (technically satisfactory) inspiratory vital capacity (IVC)? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_SecondMethod_Erv
	PX810401370302	If second method, what is the reported value more for the (technically satisfactory) expiratory reserve volume (ERV)? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Spirometer_Recalibration
	PX810401260000	If the spirometer was disassembled and more cleaned, was the device re-calibrated? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Subject_AbilityTo_Cooperate
	PX810401200000	Does the subject show signs of limited more ability to cooperate? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Subject_Age
	PX810401060000	What is the subject's age?	Variable Mapping
PX810401_Standardisation_LungVolumeMeasurement_Subject_Conditions
	PX810401030000	Does the subject suffer from any of the more following conditions: chest or abdominal pain of any cause, oral or facial pain exacerbated by a mouthpiece, stress incontinence, dementia or confusional state? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Subject_Medications
	PX810401120100	Is the subject currently taking any more medication that may alter lung function? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Subject_Medications_LastTime
	PX810401120300	If so, when was the last time the drugs were more administered? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Subject_OtherHandicap
	PX810401090100	Does the subject suffer from any handicap more which prevents an accurate measurement from standing height or arm span length? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Subject_Position
	PX810401050100	Which position will the subject be in for more the duration of the test? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Subject_Repeat_EquipmentTester
	PX810401170200	If so, is the equipment and operator from more the previous session the same? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Subject_Repeat_OrderConserved
	PX810401180000	Is the planned order of lung function tests more identical to previous tests? show less	N/A
PX810401_Standardisation_LungVolumeMeasurement_Subject_Thoracic_Deformity
	PX810401080100	Does the subject suffer from any deformity more of the thoracic cage, such as kyphoscoliosis? show less	Variable Mapping
PX810401_Standardisation_LungVolumeMeasurement_Subject_Weight
	PX810401100000	What is the subject's weight?	Variable Mapping
PX810401_Standardisation_LungVolumeMeasurement_VC
	PX810401010000	Which of the following ways is the more measurement for vital capacity taken? show less	N/A

SCD Cardiovascular, Pulmonary, and Renal

Measure Name

Lung Function - Lung Volume

Release Date

July 30, 2015

Definition

Clinical assessment to determine the volume of gas within an individual’s lung.

Purpose

This measure can be used to differentiate obstructive and restrictive pulmonary conditions and to detect and quantify symptoms associated with conditions that impact the lung, such as sickle cell disease, cystic fibrosis, and obstructive airway disease.

Keywords

Lung function, lung volume, lung physiology, diffusion capacity, D_LCO, functional residual capacity, FRC, sickle cell disease, SCD, emphysema, Cystic fibrosis, CF, asbestosis, lupus, arthritis, smoking, sarcoidosis, carbon monoxide, obstructive airway disease, Pulmonary, asthma, sleep apnea, breathing, "Cardiovascular, Pulmonary, and Renal"

Measure Protocols

Protocol ID	Protocol Name
810401	Lung Function - Lung Volume