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Substance-specific Intermediate Phenotypes

Select Protocol ID

Drug Effects Questionnaire (DEQ)
#520103

Biphasic Alcohol Effects Scale (BAES)
#520102

Addiction Research Center Inventory (ARCI)
#520101

Cigarette Evaluation Questionnaire (CEQ)
#520104

Self-Rating of the Effects of Alcohol (SRE)
#520202

Pomerleau et al, Early experiences with tobacco among women smokers, ex-smokers, and never-smokers, ADDICTION, 1998
#520201

Brief Comprehensive Effects of Alcohol questionnaire (B-CEOA)
#520406

Stimulant Effect Expectancy Questionnaire (SEEQ)
#520402

Marijuana Effect Expectancy Questionnaire (MEEQ)
#520404

Prescription Stimulant Expectancy Questionnaire (PSEQ)
#520405

The Brief Smoking Consequences Questionnaire-Adult (BSCQ-A)
#520407

The Cannabis Effects Expectancy Questionnaire–Medical (CEEQ-M)
#520408

Drinking Motives Questionnaire Revised (DMQ-R)
#520501

Monitoring the Future (MTF), 2015
#520506

Brief Wisconsin Inventory of Smoking Dependence Motives (Brief WISDM)
#520504

Comprehensive Marijuana Motives Questionnaire (CMMQ) Short Form
#520507

Drinking Motives Questionnaire Revised (DMQ-R)
#520502

International Cannabis Policy Study (ICPS), Wave 6 (2023)
#511101

National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III)
#520307

Alcohol Urge Questionnaire (AUQ)
#520301

Cocaine Craving Questionnaire-Brief (CCQ-Brief)
#520302

Heroin Craving Questionnaire - Short Form 14 (HCQ-SF-14)
#520303

Marijuana Craving Questionnaire - Short Form (MCQ-SF)
#520304

Brief Questionnaire of Smoking Urges (QSU-Brief)
#520306
Release Date:

February 24, 2012; reviewed November 21, 2016

Scope of Collection
Element Considered Final Measures in Toolkit
Sensitivity Acute Subjective Response to Substances - Current - General
Acute Subjective Response to Substances - Current - Specific - Alcohol
Acute Subjective Response to Substances - Current - Specific - Drugs
Acute Subjective Response to Substances - Current - Specific - Tobacco
Acute Subjective Responses to Substances - Retrospective - Alcohol
Acute Subjective Responses to Substances - Retrospective - Tobacco
Core features of dependence Self-reported Craving - General
Self-reported Craving - Specific - Alcohol
Self-reported Craving - Specific - Cocaine
Self-reported Craving - Specific - Heroin
Self-reported Craving - Specific - Marijuana
Self-reported Craving - Specific - Tobacco
Cognitive processes indicative (predictive) of drug dependence Expectancies - Alcohol, Cigarette Smoking, and Other Smoking - Alcohol
Expectancies - Alcohol, Cigarette Smoking, and Other Smoking - Illegal Stimulant Drugs
Expectancies - Alcohol, Cigarette Smoking, and Other Smoking - Marijuana
Expectancies - Alcohol, Cigarette Smoking, and Other Smoking - Prescription Stimulant Drugs
Expectancies - Alcohol, Cigarette Smoking, and Other Smoking - Tobacco
Motives - Alcohol, Tobacco and Other Substances - General
Motives - Alcohol, Tobacco and Other Substances - Specific - Drugs
Motives - Alcohol, Tobacco and Other Substances - Specific - Tobacco
Motives - Alcohol, Tobacco, and Other Substances - Specific - Alcohol
Working Group Roster:

WG Members:

Harriet de Wit, PhD, Co-Chair
University of Chicago
Chicago, IL
Stephanie S. O'Malley, PhD, Co-Chair
Yale University
Department of Psychology
New Haven, CT
Kathleen Bucholz, PhD
Washington University in St. Louis
St. Louis, MO
Dan Falk, PhD
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Bethesda, MD
Hank Kranzler, MD
University of Pennsylvania
Philadelphia, PA
Kenzie Preston, PhD
National Institute on Drug Abuse (NIDA)
NIDA Intramural Research Program
Rockville, MD
Ken Winters, PhD
University of Minnesota, Twin Cities
Minneapolis, MN

Substance Use, Use Disorders, and Recovery Panel Liaison, WG Manager and WG Supervisor:

Arpana Agrawal, PhD, SAA Scientific Panel Liaison
Washington University in St. Louis
St. Louis, MO
Kevin P. Conway, PhD, SAA Scientific Panel Liaison
National Institute on Drug Abuse (NIDA)
Division of Epidemiology, Services, and Prevention Research
Rockville, MD
Dana B. Hancock, PhD, WG Supervisor
RTI International
Research Triangle Park, NC
Michael Phillips, MS, WG Manager
RTI International
Research Triangle Park, NC
Substance Use and Recovery:

WG Members:

Anne Buu, PhD
University of Texas Health Science Center at Houston
Houston, TX
John Kelly, PhD
Harvard Medical School
Boston, MA
Amanda Bunting, PhD
NY Langone Medical Center
New York, NY
Denise Vidot, PhD
University of Miami
Miami, FL
Christian Hopfer, MD
University of Colorado, Denver
Denver, CO
Corrie Vilsaint, PhD
MGH Recovery Research Institute
Boston, MA
Ryan McNeil, PhD
Yale University
New Haven, CT
Sarah Zemore, PhD
Alcohol Research Group
Emeryville, CA
Johannes Thrul, PhD
Johns Hopkins University
Baltimore, MD

Substance Use and Recovery Panel Liaison, WG Manager and WG Supervisor:

Cataia Ives, MS
RTI International
Research Triangle Park, NC
Tamara Haegerich, PhD
National Institute on Drug Abuse (NIDA)
Rockville, MD
Christine Hill, MPA
RTI International
Atlanta, GA
Jyoti Dayal, MS
National Human Genome Research Institute (NHGRI)
Bethesda, MD

Supplemental Information includes protocols that the Working Group or Expert Review Panel considered useful and highly relevant to the domain but do not meet the criteria for inclusion in the Toolkit.

Substance-specific Intermediate Phenotypes Supplemental Information includes:
Additional Information:

There is no additional information for this collection.

Measure Protocols Domain/Collection
Acute Subjective Response to Substances - Current Add to My Toolkit Acute Subjective Response to Substances - Current - General Substance-specific Intermediate Phenotypes
Add to My Toolkit Acute Subjective Response to Substances - Current - Specific - Alcohol Substance-specific Intermediate Phenotypes
Add to My Toolkit Acute Subjective Response to Substances - Current - Specific - Drugs Substance-specific Intermediate Phenotypes
Add to My Toolkit Acute Subjective Response to Substances - Current - Specific - Tobacco Substance-specific Intermediate Phenotypes
Acute Subjective Responses to Substances - Retrospective Add to My Toolkit Acute Subjective Responses to Substances - Retrospective - Alcohol Substance-specific Intermediate Phenotypes
Add to My Toolkit Acute Subjective Responses to Substances - Retrospective - Tobacco Substance-specific Intermediate Phenotypes
Expectancies - Alcohol, Tobacco, and Other Substances Add to My Toolkit Expectancies - Alcohol, Cigarette Smoking, and Other Smoking - Alcohol Substance-specific Intermediate Phenotypes
Add to My Toolkit Expectancies - Alcohol, Cigarette Smoking, and Other Smoking - Illegal Stimulant Drugs Substance-specific Intermediate Phenotypes
Add to My Toolkit Expectancies - Alcohol, Cigarette Smoking, and Other Smoking - Marijuana Substance-specific Intermediate Phenotypes
Add to My Toolkit Expectancies - Alcohol, Cigarette Smoking, and Other Smoking - Prescription Stimulant Drugs Substance-specific Intermediate Phenotypes
Add to My Toolkit Expectancies - Alcohol, Cigarette Smoking, and Other Smoking - Tobacco Substance-specific Intermediate Phenotypes
Add to My Toolkit Expectancies for Medical Cannabis Use Substance-specific Intermediate Phenotypes
Motives - Alcohol, Tobacco, and Other Substances Add to My Toolkit Motives - Alcohol, Tobacco and Other Substances - General Substance-specific Intermediate Phenotypes
Add to My Toolkit Motives - Alcohol, Tobacco and Other Substances - Specific - Drugs Substance-specific Intermediate Phenotypes
Add to My Toolkit Motives - Alcohol, Tobacco and Other Substances - Specific - Tobacco Substance-specific Intermediate Phenotypes
Add to My Toolkit Motives - Alcohol, Tobacco, and Other Substances – Cannabis Substance-specific Intermediate Phenotypes
Add to My Toolkit Motives - Alcohol, Tobacco, and Other Substances - Specific - Alcohol Substance-specific Intermediate Phenotypes
Motives - Alcohol, Tobacco, and Other Substances Add to My Toolkit Motives for Using Medical Cannabis Assessment of Substance Use and Substance Use Disorders
Self-reported Craving Add to My Toolkit Self-reported Craving - General Substance-specific Intermediate Phenotypes
Add to My Toolkit Self-reported Craving - Specific - Alcohol Substance-specific Intermediate Phenotypes
Add to My Toolkit Self-reported Craving - Specific - Cocaine Substance-specific Intermediate Phenotypes
Add to My Toolkit Self-reported Craving - Specific - Heroin Substance-specific Intermediate Phenotypes
Add to My Toolkit Self-reported Craving - Specific - Marijuana Substance-specific Intermediate Phenotypes
Add to My Toolkit Self-reported Craving - Specific - Tobacco Substance-specific Intermediate Phenotypes